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12/10/2008

Table of contents

Table of contents

P-MAPA IMMUNOMODULATOR


Product Monograph


 * Orange  text links below, are provided to downloadable documents and detailed descriptions of available experimental data.


 ++ For portuguese, click here


• P-MAPA : Overview


General properties of P-MAPA


• Chemical properties

• P-Mapa- Structural formula


Mechanism of Action of P-MAPA


• Proposed mechanism of therapeutic action of P-MAPA


Preliminary Immunomodulating Activities


• Lymphoproliferative Effect of P-MAPA on Splenic Cells (under construction)

• Plaques Forming in Splenic Cells Induced by P-MAPA (under construction)


•  P-MAPA effect on human toll-like receptors (under construction)

 

• P-MAPA effect in dendritic cells development and maturation (under construction)

 


Use of P-Mapa in Disease States

Animal Models of Infection -Intracelullar pathogens


Bacteria, protozoan and virus


• Listeriosis


• Malaria


• Tuberculosis 


• Visceral leishmaniais


• Phleboviruses -Punta toro virus


• Parvovirus and Canine distemper virus 



Animal Models  of cancer


• Antitumoral Effect of P-MAPA on  urinary bladder cancer


• Antitumoral Effect of P-MAPA on Lewis lung carcinoma (3LL)


• Antitumoral Effect of P-MAPA on Renal carcinoma (RENCA)


• Antitumoral Effect of P-MAPA on Mammary Carcinoma and Plasmacitoma


• Antitumoral Effect of P-MAPA on Walker 256 Tumor


• Antitumoral Effect of P-MAPA on Prostate Tumor  

 

 


Toxicity and Safety

Toxicity in vitro and animals

Toxicity in vitro


• Preliminar Toxicity in mitochondria - Cytotoxicity -V 79 cell line

• Chromosomal Aberrations


Toxicity in Animals


Toxicity in mice


• LD50 in Mice

•Acute Toxicity in mice

• Oral Acute Toxicity in Mice (single dose)


Toxicity in Rats


• 12 Week Multiple Dose Toxicity in Rats


• Reproduction and post-natal toxicity in rats


Toxicity in mice - Teratogenicity in mice


• Effect of P-MAPA on Intra-ocular Graft Tooth Germ Development


• Effect of P-MAPA on Tooth Germ and Palate Development


Toxicity in Monkeys


• 4 Week Multiple Dose Toxicity in primates


Pharmacokinetics


• Plasma levels of P-MAPA at diferent doses in rats

 

• Pharmacocinetic parameters of P-MAPA and target organs for Mg2+ ions


Preclinical conclusions


•Animal models  (under constructon) 


Safety in Humans

• Clinical Trial Phase I - HIV + patients

• Anti-viral properties ( anti-HIV-1) in vitro

• Virus replication in vitro


Clinical Trials

HIV /AIDS


• Preliminary clinical study with AIDS patients 


 References


• Bibliographic references (under construction)

 



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